Study on Brain correlates of emotional regulation in bipolar women with premenstrual exacerbation

Monday, February 3 2014

There is evidence that women with bipolar disorder and a severe form of PMS, known as premenstrual dysphoric disorder (PMDD) have a worse course of their illness: they suffer from more frequent and severe episodes and may require hospitalization. This study is a brain imaging study that uses fMRI to track the differences in brain activation patterns as well as hormone levels between women with bipolar disorder and PMDD during two phases of the menstrual cycle.

Upon completion of the study, subjects will receive $150.00 compensation for any expenses incurred during participation.

We are looking for women ages 18-45:

a)   With or without a history of premenstrual dysphoric disorder (PMDD)

b)   With or without a history of bipolar disorder

Inclusion: Participants must have regular periods (between 25-35 days) and not be on any form of hormonal contraceptive (if recently off, must be at least 3 months).

Principal Investigator: Dr. Benicio Frey. MD, PhD.

If you are interested in participating, please contact Olivia Allega for more information by phone at our business line: 905-522-1155 ext. 33031, or, if more convenient, through email at or

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